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KMID : 0604520220480020157
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Journal of the Society of Cosmetic Scientists of Korea
2022 Volume.48 No. 2 p.157 ~ p.167
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A Novel Heptapeptide that Promotes Cellular Activity and Inhibits Photoaging in Fibroblasts
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Lee Eung-Ji
Kang Han-A
Hwang Bo-Byeol
Chung Yong-Ji
Kim Eun-Mi
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Abstract
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In this study, we investigated the effects of heptapeptide on cellular activation and inhibition of cellular damage induced by photoaging condition in NIH3T3 fibroblasts. Cell proliferation and extracellular matrix (ECM) expression were induced by heptapeptide. The reduced cell viability under photoaging condition through ultraviolet A (UVA) irradiation was increased by heptapeptide. And UVA-induced apoptosis, matrix metalloproteinases-1 (MMP-1) expression, and reactive oxygen species (ROS) level were decreased by heptapeptide. In addition, the inhibition of transforming growth factor-β (TGF-β)/smad signaling under UVA irradiation which resulting in reduction of ECM expression was also recovered by heptapeptide. We also tested the effect of heptapeptide under another photoaging condition through heat shock, and pre-treatment of heptapeptide prevented the phosphorylation of mitogen-activated protein kinase (MAPK) and MMP-1 expression induced by heat shock.
From these results, it has been shown that the heptapeptide has protective effects on fibroblasts through the up-regulation of cellular activity and through the decreasing of intracellular ROS level induced by UVA irradiation or heat shock. It is expected that the dermal protection effect of heptapeptide can be applied as a new cosmetic material in the future.
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KEYWORD
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heptapeptide, fibroblast, photoaging, reactive oxygen species, extracellular matrix
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